O17: HYALURONIC ACID DEPENDENT ADHESION IN COLORECTAL CANCER PERITONEAL METASTASIS

Abstract Introduction Peritoneal Metastasis (PM) in Colorectal Cancer (CRC) undoubtedly remains a challenge to treat and often portends poor prognosis for patients. Hyaluronic acid (HA) is found throughout the body, including coating of peritoneum. Interaction HA with HA-dependent adhesion molecules can facilitate cell within may play role spread PM CRC association known HA-receptor CD44, RHAMM ICAM-1. Method Expression HA-independent were examined using tissue microarray datasets matched clinicopathological data. In-vitro peritoneal modelling assessed cellular when treated competitive HA-inhibitor (HAi) or excess exogenous HA. An in-vivo Xenograft model, CD1 nude mice injected cells, either HAi compared control (PPL: PE9445FC2). Result There significant increase expression seen ICAM-1 (p=<0.0001). Whilst Non-HA-dependent demonstrated downregulation no difference. Cellular was decreased three lines Treatment confirmed reduction PM, controls (HAi p=0.0094, p=0.0009). Conclusion appear CRC. Targeting interaction influences have potential therapeutic use treatment Further in-vitro vivo needed. Take-home message receptor all been independently implicated adverse outcomes colorectal cancer. appears reduce dissemination